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Determining Optimum Maintenance Temperature for Advanced Therapies, Part 1

As referenced in a previous blog post, understanding the proper method of safely cryopreserving your material is essential, but of equal importance is determining the optimum maintenance temperature. There are many factors that need to be considered when selecting an effective maintenance temperature. Those factors include volume, handling processes, storage and handling equipment and the impact of multiple short duration exposures. In this two part blog series, we’ll discuss four areas that need to be understood to determine the optimum maintenance temperature for advanced therapy material.

Topic: Biobanking and Biorepository, Topic: Cold-C..........

24 Hours of Stem Cells

Stem cell research is one of the fastest growing areas in science. This is largely due to its immense potential to impact the future of medicine and how we treat diseases. Whether in basic research or advanced therapy applications, Fisher BioServices is committed to the expansion of this field. To facilitate knowledge sharing and collaboration, Thermo Fisher Scientific is hosting the 5th Annual 24 Hours of Stem Cells event - the day the world revolves around stem cells.

Topic: Cell Therapy Solutions, Content: Blog

Cell & Gene Meeting on the Mesa 2017

The advancements in advanced therapy are increasing at a rapid pace and are transforming the way we think about medicine. Whether in research or in the clinic, scientific innovators are acutely aware that every moment counts when working with these valuable therapies. To facilitate knowledge sharing and collaboration, we are pleased to announce our participation as a gold sponsor at the Cell & Gene Meeting on the Mesa in La Jolla, California.

Topic: Cell Therapy Solutions, Content: Blog

Halting the Next Ebola Epidemic

Prior to 2014 Ebola was mostly seen as a deadly disease, but contained in remote areas of the world with a low likelihood of spreading. However, this false impression was dispelled when the disease hit heavily populated urban areas. Suddenly the world realized the Ebola outbreaks could reach epidemic proportions, and with an average fatality rate of approximately 50%, the potential impact could be catastrophic. In response, the scientific community rushed to develop a vaccine.

Topic: Biobanking and Biorepository, Topic: Public..........

Global Biobank Week: Towards Harmony in Biobanking

Hospitals, biopharmaceutical companies and academic researchers rely on biobanks and biorepositories for the most critical piece of the puzzle – biological samples and their associated data. Biobanks play an important role in enabling researchers to develop therapies for chronic diseases. They are key components in the research of new treatments and the identification of disease biomarkers from the large cohorts of patients through the collection, storage, inventory, characterization and distribution of valuable samples.

Thus, we are pleased to announce our participation at the upcoming Global Biobank Week (GBW) 2017 in Stockholm, Sweden.  GBW provides a global platform for comprehensive discussion and collaboration on activities important for biobanking and biopreservation of samples and data to improve healthcare and decrease the burden of disease worldwide.

Whether you’re managing the inventory of a freezer or an entire biorepository, we have a solution for all of your biobanking needs.  For decades, customers have relied on our biobanking solutions and services to preserve sample quality and improve efficiency at every stage of the workflow.  From sample collection and preparation, to sample analysis and sequencing, to cold storage and automation, we have the equipment, consumables, software systems, and full services needed to ensure reliable, efficient sample management and monitoring.

 

Come visit us at booth #26 for a chance to win a portable power bank and to check out our interactive virtual biobankWe look forward to sharing our solutions with you and discussing the latest breakthroughs in biobanking.  In the meantime, check out our eBook Biobank: Should you build or outsource?. It presents 10 questions to consider before you decide to build or outsource a biobank project, important components and costs for building and managing a biobanking, and some additional resources.

Download eBook

Topic: Biobanking and Biorepository, Content: Blog

Controlling Complexity [Not Cost] of Advanced Therapy Supply Chain

Due to the short shelf life and clinical criticality of advanced therapies, their supply chains are often highly complex.  Once efficacy and safety is demonstrated, the focus of advanced therapy developers moves to controlling cost.  However, the biggest cost within the supply chain is caused by its complexity.  In this blog we will share why the advanced therapy supply chain is so complex and how this complexity correlates to cost.

Topic: Cell Therapy Solutions, Content: Blog

Importance of Early Planning for Cell Therapy Clinical Trials

As discussed in previous blog articles, early planning is critical, both for cell therapy clinical trials and commercial-scale operations. By addressing how activities will be managed early on, it can minimize risk and cost, and optimize downstream processes. However, oftentimes clients are unsure of which components are critical to address early on.

Topic: Cell Therapy Solutions, Content: Blog

Next-Gen Bioinformatics: The Expanding Role of Deep-Learning Algorithms

Deep-learning algorithms have shown significant promise as applications in natural language understanding, decision making, and speech and image recognition. These algorithms are now being applied in bioinformatics applications within the biopharma industry to manage the increasing amounts of data from high-throughput techniques. As a bioinformaticist, I am particularly fascinated with recent applications of these algorithms to predict a variety of biological processes and interactions, particularly with respect to proteins. 

Topic: Biobanking and Biorepository, Topic: Labora..........

CRISPR-Cas9 Off-Target Effects

In our previous blogs on cell therapy solutions, we summarized the CRISPR-Cas (Clustered, Regularly Interspersed, Short Palindromic Repeats) system as a remarkable tool for greatly simplifying gene manipulation (insertions, deletions, development of knock-in and knock-out animal models).  Also described were ways to study epigenetic processes by ‘borrowing’ the Cas9 nuclease from the CRISPR system to pair with histone acetylation domains for induction of acetylation at specific sites.  For instance, one application of this capability could be applied in gene therapy, whereby incorporation of epigenetic changes could achieve gene silencing of abnormally activated genes, or by controlling stem cell differentiation.

Topic: Cell Therapy Solutions, Content: Blog

The RMAT Designation: What it means to the advanced therapy supply chain

The ever-increasing demand for healthcare advances has prompted legislators to consider means of facilitating the development of potentially life-saving new therapies. In this guest blog, Alison Wilson will review the definition of a regenerative medicine advanced therapy (RMAT) and how this designation can facilitate speed to market for these innovative therapies.  Alison is an independent regulatory affairs consultant specializing in human cell and tissue-based advanced therapies.

Topic: Cell Therapy Solutions, Content: Blog

Conducting the Advanced Therapy Supply Chain Orchestra

A coordinated supply chain management plan is crucial when developing advanced therapies.

Topic: Cell Therapy Solutions, Content: Blog

Minimizing Waste through Practical Process Improvement

Personal Protective Equipment (PPE) is necessary to ensure the safety of personnel in a biopharma environment.  However, have you ever considered the amount of waste that accumulates from the use of laboratory nitrile gloves and other single use apparel?

Topic: Biobanking and Biorepository, Topic: Labora..........