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Receiving Finished Pharmaceuticals at the Repository

The value of your work lies in the integrity of your materials. Ensuring pharmaceutical agents are handled properly and maintained at the correct temperature throughout all processes is imperative to maximal long term viability and usability. This means not only during the processing and preparation of finished pharmaceuticals for storage—it also means during the transportation process

Topic: Biobanking and Biorepository, Topic: Cold-C..........

Supporting the Precision Medicine Initiative: The All of Us Research Program

In 2015, President Obama announced the Precision Medicine Initiative, a new effort to revolutionize health and disease treatment.1 Two key components of this initiative are:

Topic: Biobanking and Biorepository, Topic: Labora..........

Determining Optimum Maintenance Temperature for Advanced Therapies, Part 2

As discussed in my previous blog, there are many factors that need to be considered when selecting an effective maintenance temperature. Those factors include volume, handling processes, storage, and equipment. In part two of this blog series, I will focus on the impact that some of these variables can have on determining an optimum maintenance temperature for advanced therapies.

Topic: Biobanking and Biorepository, Topic: Cold-C..........

Risk Mitigation for Material Transport: The Impact of Re-Using Shippers

Ensuring your material is stored under appropriate conditions is only half the battle in preserving its integrity. Equally as critical is the precarious process of transporting your material to its destination, safely and in the same condition it was sent in. Maintaining the chain of custody is of utmost importance, and a large component of this is based on the vessel selected for transportation. In this blog I will share some key items to consider when selecting shippers to transport your high value material.

Topic: Biobanking and Biorepository, Topic: Cold-C..........

Thinking Outside of the Freezer: DNA and RNA Storage

While ultra-low temperatures are the current state-of-the-art solution for biospecimen storage, ambient storage is an interesting option and could be superior in certain limited situations. For many types of samples it’s possible that we will always have to use ultra-low temperatures for long-term storage. For other sample types, such as DNA and RNA, there are alternative solutions.  

Topic: Biobanking and Biorepository, Topic: Public..........

Fisher BioServices Top Five Most Popular Blogs of 2017

2017 has been a year filled with new discoveries in the health and medical R&D space. Through our blog, we have shared great stories of our customers' work and discussed a wide-breadth of topics, focusing on advanced therapies, biological material, and public health research.

Topic: Biobanking and Biorepository, Topic: Cold-C..........

InsideAccess: Minimizing Errors and Saving Time in Drug Receipt Processes

The speed-accuracy trade-off is a well-known phenomenon in psychology for processes requiring human input: the faster you go, the more likely it is that errors will be introduced into the system. This presents a major challenge for complex supply chains that demand both efficiency and accuracy. For example, when handling and distributing sensitive clinical materials, it is essential that the workflow proceed as quickly as possible while minimizing errors.

Topic: Biobanking and Biorepository, Content: Insi..........

World AIDS Day 2017

December 1st is World AIDS Day. Each year, this day is an opportunity to raise awareness of the AIDS pandemic, unite in the fight against HIV, and remember those lost to an AIDS-related illness. The 2017 World AIDS Day theme is “Increasing Impact through Transparency, Accountability, and Partnerships”. This theme reflects a shift in attitude from crisis toward control, and the role of partnerships in reaching our collective goals.

Topic: Biobanking and Biorepository, Topic: Public..........

Transitioning to a New Biobank Model at a Time of Change: An AstraZeneca & Fisher BioServices Perspective

The AstraZeneca (AZ) UK Biobank offers long-term storage of, and rapid access to, ~1 million human biological samples (HBS) from AZ Oncology clinical trials, collaborators and commercial sources. A variety of sample types are managed including normal tissue, tumor tissue, blood/plasma/serum, urine and other excreta, FFPE blocks, glass slides and genetic samples (DNA/blood).

Topic: Biobanking and Biorepository, Content: Post..........

Determining Optimum Maintenance Temperature for Advanced Therapies, Part 1

As referenced in a previous blog post, understanding the proper method of safely cryopreserving your material is essential, but of equal importance is determining the optimum maintenance temperature. There are many factors that need to be considered when selecting an effective maintenance temperature. Those factors include volume, handling processes, storage and handling equipment and the impact of multiple short duration exposures. In this two part blog series, we’ll discuss four areas that need to be understood to determine the optimum maintenance temperature for advanced therapy material.

Topic: Biobanking and Biorepository, Topic: Cold-C..........

Distributed Biobanking: An End to End Solution for FFPE Tissue Block Management

The process of formalin-fixed paraffin-embedding (FFPE) emerged in the late 19th century as a valuable histological method for stabilizing and preserving the morphology and cellular details of tissue samples. Additional advantages of preserving  tissues using the FFPE technique included long term room temperature storage without fear of degradation, and if tissues were correctly preserved, FFPE blocks could be used over decades to prepare additional slides for microscopic analysis (as long as there was remaining tissue in the paraffin block) with little or no tissue degradation. Significant advances in protein and nucleic acid isolation techniques from FFPE tissues have resulted in the generation of sufficient amounts of nucleic acid which can be used in a wide range of analytical techniques for the determination of structure and function of these key biological molecules.

Topic: Biobanking and Biorepository, Topic: Labora..........

The Effect of Pre-analytical Variables on Plasma Samples Stored in Biobanks

Differences detected in respective biospecimen collections are more dependent on pre-analytical variables than on the inherent differences among the samples. Therefore, there is a parallel emphasis on standard protocol for biological sample collection and storage and identifying specific biomarkers as quality controls to assess the effects of pre-analytical factors on variability in the results. Mateos et al. (2016) used different, complementary proteomic techniques in separate, coordinated laboratories to search for quality biomarkers that would allow assessment of integrity and purity of plasma samples stored in biobanks.1

Topic: Biobanking and Biorepository, Topic: Labora..........