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Determining Optimum Maintenance Temperature for Advanced Therapies, Part 1

As referenced in a previous blog post, understanding the proper method of safely cryopreserving your material is essential, but of equal importance is determining the optimum maintenance temperature. There are many factors that need to be considered when selecting an effective maintenance temperature. Those factors include volume, handling processes, storage and handling equipment and the impact of multiple short duration exposures. In this two part blog series, we’ll discuss four areas that need to be understood to determine the optimum maintenance temperature for advanced therapy material.

Topic: Cell Therapy Solutions, Content: Blog, Topi..........

Distributed Biobanking: An End to End Solution for FFPE Tissue Block Management

The process of formalin-fixed paraffin-embedding (FFPE) emerged in the late 19th century as a valuable histological method for stabilizing and preserving the morphology and cellular details of tissue samples. Additional advantages of preserving  tissues using the FFPE technique included long term room temperature storage without fear of degradation, and if tissues were correctly preserved, FFPE blocks could be used over decades to prepare additional slides for microscopic analysis (as long as there was remaining tissue in the paraffin block) with little or no tissue degradation. Significant advances in protein and nucleic acid isolation techniques from FFPE tissues have resulted in the generation of sufficient amounts of nucleic acid which can be used in a wide range of analytical techniques for the determination of structure and function of these key biological molecules.

Topic: Laboratory Processing, Topic: Biobanking an..........

The Effect of Pre-analytical Variables on Plasma Samples Stored in Biobanks

Differences detected in respective biospecimen collections are more dependent on pre-analytical variables than on the inherent differences among the samples. Therefore, there is a parallel emphasis on standard protocol for biological sample collection and storage and identifying specific biomarkers as quality controls to assess the effects of pre-analytical factors on variability in the results. Mateos et al. (2016) used different, complementary proteomic techniques in separate, coordinated laboratories to search for quality biomarkers that would allow assessment of integrity and purity of plasma samples stored in biobanks.1

Topic: Biobanking and Biorepository, Topic: Labora..........

Halting the Next Ebola Epidemic

Prior to 2014 Ebola was mostly seen as a deadly disease, but contained in remote areas of the world with a low likelihood of spreading. However, this false impression was dispelled when the disease hit heavily populated urban areas. Suddenly the world realized the Ebola outbreaks could reach epidemic proportions, and with an average fatality rate of approximately 50%, the potential impact could be catastrophic. In response, the scientific community rushed to develop a vaccine.

Topic: Biobanking and Biorepository, Topic: Public..........

Global Biobank Week: Towards Harmony in Biobanking

Hospitals, biopharmaceutical companies and academic researchers rely on biobanks and biorepositories for the most critical piece of the puzzle – biological samples and their associated data. Biobanks play an important role in enabling researchers to develop therapies for chronic diseases. They are key components in the research of new treatments and the identification of disease biomarkers from the large cohorts of patients through the collection, storage, inventory, characterization and distribution of valuable samples.

Thus, we are pleased to announce our participation at the upcoming Global Biobank Week (GBW) 2017 in Stockholm, Sweden.  GBW provides a global platform for comprehensive discussion and collaboration on activities important for biobanking and biopreservation of samples and data to improve healthcare and decrease the burden of disease worldwide.

Whether you’re managing the inventory of a freezer or an entire biorepository, we have a solution for all of your biobanking needs.  For decades, customers have relied on our biobanking solutions and services to preserve sample quality and improve efficiency at every stage of the workflow.  From sample collection and preparation, to sample analysis and sequencing, to cold storage and automation, we have the equipment, consumables, software systems, and full services needed to ensure reliable, efficient sample management and monitoring.

 

Come visit us at booth #26 for a chance to win a portable power bank and to check out our interactive virtual biobankWe look forward to sharing our solutions with you and discussing the latest breakthroughs in biobanking.  In the meantime, check out our eBook Biobank: Should you build or outsource?. It presents 10 questions to consider before you decide to build or outsource a biobank project, important components and costs for building and managing a biobanking, and some additional resources.

Download eBook

Topic: Biobanking and Biorepository, Content: Blog

Use of Mobile Technology to Enhance Biospecimen Quality and Biobank Efficiency

Population-based biobanking is an essential aspect of biomedical research. When biobank samples are collected outside of clinical or research facilities, chances for variation in sample collection, handling, and shipping increase. Any lack of standardization before, during, or after collections can generate unwanted pre-analytical variability that hurts future use of biospecimens.

Topic: Biobanking and Biorepository, Topic: Public..........

Next-Gen Bioinformatics: The Expanding Role of Deep-Learning Algorithms

Deep-learning algorithms have shown significant promise as applications in natural language understanding, decision making, and speech and image recognition. These algorithms are now being applied in bioinformatics applications within the biopharma industry to manage the increasing amounts of data from high-throughput techniques. As a bioinformaticist, I am particularly fascinated with recent applications of these algorithms to predict a variety of biological processes and interactions, particularly with respect to proteins. 

Content: Blog, Topic: Public Health Research, Topi..........

Importance of Chain of Custody Documentation for Biologics

Preventing patients from receiving “counterfeit, diverted, sub-potent, substandard, adulterated, misbranded, or expired drugs” is a critical element of the mission of the US Food and Drug Administration (FDA). The protection of the pharmaceutical supply chain is one of the FDA’s highest priorities, and chain of custody is one of the FDA’s primary tools in this mission. Chain of custody, when correctly executed, allows determination of “who, what, and when” with a high level of confidence. For advanced therapies—those derived or generated through biotechnology—chain of custody not only includes verification of “who, what, and when,” but also “at what temperature.”

Topic: Cell Therapy Solutions, Topic: Cold-Chain L..........

Minimizing Waste through Practical Process Improvement

Personal Protective Equipment (PPE) is necessary to ensure the safety of personnel in a biopharma environment.  However, have you ever considered the amount of waste that accumulates from the use of laboratory nitrile gloves and other single use apparel?

Topic: Biobanking and Biorepository, Topic: Labora..........

Keeping It Cool: Protecting Cryopreserved Biological Samples from Degradation

As discussed on the Inside Biobanking blog, cryopreservation requires a slow cooling process to reach temperatures at or near the temperature of liquid nitrogen (−196°C). This method is standard practice in preserving biological samples. In their recent review, Woods et al. (2016) examined cryobiology applications in cryopreservation to identify new solutions to integrate into mainstream cell therapy.1

Topic: Cell Therapy Solutions, Content: Blog, Topi..........

The Importance of Inventory Management: Do You Know Where Your Samples Are?

With the exciting advances in research and drug development, the importance of sample management has never been higher. If you have ever experienced sample management mishaps, we ask: Do you know where your samples are?

Topic: Biobanking and Biorepository, Content: Blog..........

Sample Integrity You Can Bank On: ISBER 2017 Annual Meeting

We are pleased to announce our participation at the International Society for Biological and Environmental Repositories (ISBER) 2017 Annual Meeting in Toronto, Ontario, Canada. This year's theme, Due North: Aligning Biobanking Practice with Evolving Evidence and Innovation. ISBER 2017 is the premier global event in the field of biorepository and specimen management and we are honored to showcase our services and products in conjunction with our parent company, Thermo Fisher Scientific at Booth #215.

Topic: Biobanking and Biorepository, Content: Blog