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Sample Fidelity: Authenticate Your Cell Lines, Protect Your Research

In July, 2007 Dr. Roland Nardone, Professor Emeritus of the Discovery Center for Cell and Molecular Biology of the Catholic University of America, and 18 of his colleagues penned a powerful letter regarding the topic of misidentification and cross-contamination of cell lines to Michael O. Leavitt, then Secretary of Health and Human Services. The 18 researchers who added their signatures to the letter represented both extensive experience in cell culture and a cross-sample of governmental, corporate, and academic institutions in the US and the UK. In his letter, Nardone informed Secretary Levitt of the extent of misidentification of cell lines being distributed amongst scientists and warned of the “resulting corruption of biomedical research” and “grave public health consequences.” He urged both an educational initiative about misidentified call lines and a specific mechanism by funding agencies to ensure the authentication of cell lines: no authentication, no funding.

Topic: Laboratory Processing

Know Your Samples – How Resilient are your Biomarkers?

biobanking samples

For all types of biomarker research, whether academic studies or clinical trials, the target analytes within your samples are the most important elements to safeguard. No matter if it’s as simple as the pH of a serum sample or as specific as the quaternary structure of a protein complex, any biomarker can be affected and potentially compromised by a number of external factors, most easily temperature.

Topic: Laboratory Processing, Content: Blog

Minimizing Your Sample Freeze/Thaw Cycle to Maintain Sample Integrity

Laboratory_Processing_Digram_to_Aliquot_or_NotIn designing clinical studies, much thought is given to controlling for clinical and demographic variability. For example, a well-designed study will carefully enroll patients of a particular disease type, stage, and treatment regimen. In addition, for each of these variables there will be determinations made as to how many patients of what age, sex, and ethnicity should be included in each of the clinical groups. By carefully considering the sample size needed for each variable, clinicians target specific and meaningful data when analyzing the results.

Topic: Laboratory Processing, Content: Blog

[Video] The Journey of a Sample... in the Biobank Laboratory

So much depends on the subtle variations in biospecimens: these variations, when analyzed via genomics, proteomics, metabolomics, and similar studies, are the foundation of both disease-based and drug-based biomarker discovery. And if the unique "-omics" of a sample is to yield results that lead to improvements in medical research and healthcare, such as understanding disease cause/progression (predictive/prognostic biomarker) to PK/PD in clinical trials (surrogate endpoints), then the entire integrity of the specimen must be protected, or biomarker research/study can go astray. 

Content: Video, Topic: Laboratory Processing

National Children's Study Shows Why Biobanking Automation Pays Off

National Children's Study

Topic: Biobanking and Biorepository, Content: Post..........

Got Enough DNA?

With funding the way it is today, long gone is the era of producing unlimited DNA from study participants' cell lines.  Many study coordinators are faced with the challenge of how to manage the limited amount of DNA collected from participants during a clinical trial.  Through years of working with many clients involved in clinical trials and cohort studies, I've summarized some of the important considerations that can help you manage this invaluable resource. 

Topic: Laboratory Processing, Content: Blog

Free Webinar - Laboratory Processing, Automation, and Analysis for Biobank Samples and Clinical Biospecimens

Biobanks and clinical translational research centers play a critical role in the research information network, and often requires a LIMS (Laboratory Information Managmenet System) integrated workflow from sample receipt through processing, analysis, and storage/preservation. Today, many labs are facing bottlenecks in their workflow. Michael Blackburn, a senior research investigator at Sanofi-Aventis, commented about lab bottlenecks in a recent article "Improving Workflows In An Analytical Laboratory", "Analytical labs face a number of bottlenecks, depending of course on what they are analyzing and whether or not they are in a regulated environment".

Topic: Laboratory Processing, Content: Webinar