Population-based biobanking is an essential aspect of biomedical research. When biobank samples are collected outside of clinical or research facilities, chances for variation in sample collection, handling, and shipping increase. Any lack of standardization before, during, or after collections can generate unwanted pre-analytical variability that hurts future use of biospecimens.
In order to have confidence in both laboratory assay results and their associations with other data, the biospecimens must be correctly collected, processed, shipped, and stored. If these samples were subjected to conditions that compromised their molecular integrity—inappropriate temperatures, contaminated containers, and others—then the results of the study may also be questionable. This is an issue that must be thoroughly addressed in public health research—the possibility that the handling of specimens before laboratory testing (i.e., pre-analytical variability) has skewed results. For this reason, controlling pre-analytical variability requires the same attention to detail as the design of questionnaires.
Through the California Teachers Study, Fisher BioServices and City of Hope have implemented a comprehensive approach to improve efficiency and maintain standardization and biospecimen quality in large-scale biobanking. Download our joint webinar to learn how collaboration and utilization of integrated mobile technology has essentially eliminated pre-analytical variability in the biobanked samples.